Main
Education
Postgraduate Institute of Medical Education and Research, Paediatric Haematology Oncology
PhD in Medical Molecular biology
Chandigarh, India
2020 - 2016
Thesis: In-vitro BCR-ABL gene silencing in paediatric CML using CRISPR Cas system
Punjabi University, Department of Microbiology
MSc in Microbiology
Patiala, India
2011 - 2009
Thesis: Cloning and overexpression of murA gene of Escherichia coli
Panjab University, Department of Microbiology
BSc in Microbiology
Chandigarh, India
2009 - 2006
Research Experience
Bioinformatician
University of Gothenburg, Core Facilities
Gothenburg, Sweden
Current - 2025/01
Postdoctoral Researcher
Karolinska Institutet, Clinical Neurosciences (Robert Harris Group)
Solna, Sweden
2024/12 - 2022/11
- ALS patient driven multi-omic data analysis (RNA-seq, scRNAseq, WGS) and gene regulatory network inference
- Integration of the multiome with patient pathophysiology and clinical data for disease dynamics interpretation using deep learning
- Development of individualized ALS patient disease dynamic models for improved clinical decision making
- Understanding the mammalian regeneration process using temporal differential gene expression analysis
- Supervision of ERASMUS master’s students
- Teaching bioinformatics to the students of the Master’s program at Karolinska Institutet
Postdoctoral Researcher
Stanford Medicine, Department of Cardiology (Ashley Group)
Stanford, USA
2022/11 - 2021/01
- Designing of recombinant AAVs for improved cardiac tropism and immunogenic properties with a focus on hypertrophic cardiomyopathy
- Temporal multi-omics study of human performance and aging using RNA-seq, WGS, ATAC-seq and proteomics (MoTrPAC consortium)
- Development of Google cloud based platform for enabling the study
Graduate Student
Postgraduate Institute of Medical Education and Research, Paeditric Haematology Oncology
Chandigarh, India
2020 - 2016
- Worked on knocking down the tumorigenicity of BCR-ABL chimeric gene in chronic myeloid leukemia cell line using CRISPR Cas13a
- Achieved a 4.5 times reduction in the downstream effects of the chimeric gene and 373x reduction in viability of the cancerous cells
- Developed novel diagnostics based on targeted next generation sequencing
- Bioinformatic platform development for clinical data handling
- Deep learning algorithms for accurately filtering true variant calls from next generation sequencing data.
Select Publications
Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures
Cell Genomics
[DOI] (https://doi.org/10.1016/j.xgen.2023.100421)
2024
Nair VD, Pincas H, Smith GR, Zaslavsky E, Ge Y, Amper MAS, Vasoya M, Chikina M, Sun Y, Raja AN, Mao W, Gay NR, Esser KA, Smith KS, Zhao B, Wiel L, Singh A, Lindholm ME, Amar D, Montgomery S, Snyder MP, Walsh MJ, Sealfon SC; MoTrPAC Study Group.
Genetic architecture of cardiac dynamic flow volumes
Nature Genetics
2023
Bruna Gomes, Aditya Singh, Jack W O’Sullivan, David Amar, Mykhailo Kostur, Francois Haddad, Michael Salerno, Victoria N. Parikh, Benjamin Meder, Euan A. Ashley
Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a
Current Gene Therapy 2021;21(3):270-277
2021
Aditya Singh, Prateek Bhatia
Comparative sequencing data analysis of Ion Torrent and MinION sequencing platforms using a clinical diagnostic haematology panel
Int J Lab Hem 42, 833– 841
2020
Aditya Singh, Prateek Bhatia
Talks and conferences
The cell autonomous effects on sporadic ALS onset and survival
ENCALS Meeting (Poster)
Barcelona, Spain
2023
Aditya Singh, Stefan Wouters, Sebastian A. Lewandowski
Cloud genomics platform for precision medicine
GREGoR, US (Talk)
Virtual
2022
Aditya Singh
Uncovering genetic secrets
Undiagnosed Diseases Network, US (Talk)
Virtual
2022
Aditya Singh
Robust, reproducible, and rapid end-to-end genomics data analysis
NIH MoTrPAC DQAR (Talk)
Virtual
2021
Aditya Singh
Recognition
PhD Scholarship
PGIMER (top 5 in entrance exam)
Chandigarh, India
2020 - 2016
Dr JC Patel Best paper award
ISHBT, India
New Delhi, India
2019
RNA targeted CRISPR Cas13a effectively downregulates BCR- ABL1 tumorigenicity in vitro
Hematocon (Best scientific paper award)
New Delhi, India
2019
Multiple and repetitive variations in TMPRSS6 gene in pediatric cohort with iron refractory iron deficiency anemia (IRIDA) phenotype.
Best of ASH CME in Hematology (Top three abstracts)
Mumbai, India
2017
BCR-ABL1 chimeric gene silencing using CRISPR-Cas9 technique: Initial cell culture data
iCMLf 19th Annual John Goldman COnference on CML (Top five abstracts)
Estoril, Portugal
2017
LEUKA International Scholarship
LEUKA
London, UK
2017
Chuttani Fund
TTV Chuttani Trust
Chandigarh, India
2017
International Travel Grant
Immunology Foundation
New Delhi, India
2017